Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, California, USA.
Am J Perinatol. 2012 Mar;29(3):203-10. doi: 10.1055/s-0031-1285094. Epub 2011 Aug 4.
We examined the effects of prenatal methamphetamine (MA) exposure on growth parameters from birth to age 3 years. The 412 subjects included (n = 204 exposed) were enrolled at birth in the Infant Development, Environment and Lifestyle study, a longitudinal study assessing the effects of prenatal MA exposure on childhood outcomes. Individual models were used to examine the effects of prenatal MA exposure on weight, head circumference, height, and weight-for-length growth trajectories. After adjusting for covariates, height trajectory was lower in the exposed versus the comparison children (p = 0.021) over the first 3 years of life. Both groups increased height on average by 2.27 cm per month by age 3 years. In term subjects, MA exposure was also associated with a lower height trajectory (p = 0.034), with both the exposed and comparison groups gaining 2.25 cm per month by age 3 years. There was no difference in weight, head circumference, or weight-for-length growth trajectories between the comparison and the exposed groups. Children exposed prenatally to MA have a modest decrease in height growth trajectory during the first 3 years of life with no observed difference in weight, head circumference, or weight-for-length trajectories.
我们研究了产前甲基苯丙胺（MA）暴露对出生至 3 岁生长参数的影响。412 名受试者（n = 204 名暴露）在婴儿发育、环境和生活方式研究中出生时被纳入，这是一项纵向研究，评估了产前 MA 暴露对儿童结局的影响。个体模型用于研究产前 MA 暴露对体重、头围、身高和体重长度生长轨迹的影响。在调整协变量后，暴露组的身高轨迹在生命的前 3 年低于对照组（p = 0.021）。两组儿童在 3 岁时平均每月身高增加 2.27 厘米。在足月儿童中，MA 暴露也与较低的身高轨迹相关（p = 0.034），暴露组和对照组在 3 岁时每月身高增加 2.25 厘米。对照组和暴露组在体重、头围或体重长度生长轨迹方面没有差异。产前暴露于 MA 的儿童在生命的前 3 年内身高生长轨迹略有下降，但体重、头围或体重长度生长轨迹无明显差异。
