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[莪术与温莪术姜黄素提取物在大鼠体内的药代动力学比较研究]

[Comparative study on pharmacokinetics of curcumin extract of rhizoma curcumae longae and rhizoma wenyujin concisum in rats].

作者信息

Yao Guo-xian, Han Gang, La Wan-ying, Bi Rui, Wang Cheng-qiang

机构信息

Fengrun district People Hospital, Tang shan 064000, China.

出版信息

Zhong Yao Cai. 2011 Jan;34(1):88-91.

PMID:21818976
Abstract

OBJECTIVE

To compare the pharmacokinetics of curcumin extracted from Rhizoma Curcumae Longe and Rhizoma Wenyujin Concisum in rats.

METHODS

Sprague Dawley rats were administrated extracts of Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum. The pharmacokinetic parameters were calculated with 3P97 program.

RESULTS

The plasma concentration-time curves of curcumin that extracted from Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum were fitted with one-compartment model respectively. The AUC and Cmax of curcumin extracted from Rhizoma Curcumae Longae were much greater than of extracted from Rhizoma Wenyujin Concisum.

CONCLUSION

There were significantly difference in pharmacokinetic parameters of curcumin in Rhizoma Curcumae Longae and Rhizoma Wenyujin Concisum in rats.

摘要

目的

比较温莪术与广西莪术提取物姜黄素在大鼠体内的药代动力学。

方法

将温莪术与广西莪术提取物给予斯普拉格-道利大鼠。采用3P97程序计算药代动力学参数。

结果

温莪术与广西莪术提取物姜黄素的血药浓度-时间曲线分别符合一室模型。温莪术提取物姜黄素的AUC和Cmax远大于广西莪术提取物姜黄素。

结论

温莪术与广西莪术提取物姜黄素在大鼠体内的药代动力学参数存在显著差异。

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