Division of Community, Environment, and Policy, Mel & Enid Zuckerman College of Public Health, The University of Arizona, Tucson, Arizona, USA.
Foodborne Pathog Dis. 2011 Nov;8(11):1229-34. doi: 10.1089/fpd.2011.0925. Epub 2011 Aug 5.
The objective of this study was to investigate the association between ceftiofur use policy in finishing swine barns and recovery of fecal Escherichia coli or Salmonella spp. resistant to ceftriaxone. The study population included 54 finishing swine barns from three companies located in North Carolina. The barns were each classified according to their reported therapeutic ceftiofur use rates of "Rare," "Moderate," and "Common." Fecal samples from the barns were cultured for the presence of E. coli and Salmonella spp. resistant to ceftriaxone using selective media designed to recover rare organisms expressing the AmpC β-lactamase phenotype. A total of 1899 swine fecal samples yielded 1193 E. coli (63%) resistant to ceftriaxone. Recovery rates by ceftiofur use classification were 45% for Rare, 73% for Moderate, and 68% Common ceftiofur use groups. Barns reporting Rare ceftiofur use had a lower odds of recovery of E. coli (OR=0.32; p<0.001) resistant to ceftriaxone compared to Common use barns. The overall Salmonella spp. prevalence was 63.8% (n=714). Of these, 65 Salmonella were resistant to ceftriaxone with the highest rate (6%) found in the Common ceftiofur use group, followed by Rare (4.1%) and Moderate (0.15%). The odds of recovery of Salmonella resistant to ceftriaxone were similar for barns with ceftiofur use classified as Rare and Common. Samples from barns with ceftiofur use classified as Moderate had a lower odds (OR=0.02; p<0.01) of recovery of Salmonella resistant to ceftriaxone than barns classified as Common. Our result is consistent with the hypothesis that the use of ceftiofur in finishing swine barns, beyond its rare application, may influence the recovery of enteric E. coli with resistance to cephalosporin drugs, although other unmeasured factors appear to be important in the recovery of cephalosporin-resistant Salmonella. The dissemination of enteric bacteria with resistance to cephalosporins has the potential to impact both veterinary and human therapeutic treatment options.
本研究旨在探讨猪舍中头孢噻呋的使用政策与耐头孢曲松粪肠球菌或沙门氏菌回收之间的关联。研究人群包括来自北卡罗来纳州的三家公司的 54 个育肥猪舍。根据报告的治疗性头孢噻呋使用率，将每个猪舍分为“罕见”、“中度”和“常见”。使用专门设计用于回收表达 AmpC β-内酰胺酶表型的稀有生物体的选择性培养基，从猪舍的粪便样本中培养出对头孢曲松耐药的大肠杆菌和沙门氏菌。1899 份猪粪便样本共检出 1193 株耐头孢曲松的大肠杆菌（63%）。头孢噻呋使用分类的回收率分别为罕见组 45%、中度组 73%和常见组 68%。报告罕见头孢噻呋使用的猪舍中，对头孢曲松耐药的大肠杆菌（OR=0.32；p<0.001）的回收率较低。沙门氏菌的总体流行率为 63.8%（n=714）。其中，65 株沙门氏菌对头孢曲松耐药，最高耐药率（6%）见于常见头孢噻呋使用组，其次是罕见组（4.1%）和中度组（0.15%）。头孢噻呋使用分类为罕见和常见的猪舍中，对头孢曲松耐药的沙门氏菌的回收率相似。头孢噻呋使用分类为中度的猪舍中，对头孢曲松耐药的沙门氏菌的回收率较低（OR=0.02；p<0.01），而常见分类的猪舍中。我们的结果与以下假设一致，即在育肥猪舍中使用头孢噻呋（除了罕见应用）可能会影响对头孢菌素类药物耐药的肠内大肠杆菌的回收，尽管其他未测量的因素似乎对头孢菌素类耐药沙门氏菌的回收很重要。对头孢菌素类耐药肠内细菌的传播有可能影响兽医和人类的治疗选择。
