Department of Psychiatry and Pharmacology, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 125 S, 31st St. TRL Rm 2207, Philadelphia, PA 19104, USA.
Nitric Oxide. 2011 Oct 30;25(3):255-64. doi: 10.1016/j.niox.2011.07.002. Epub 2011 Jul 26.
The biosynthesis of nitric oxide (NO) and prostaglandin share many similarities. Two major forms of nitric oxide synthase (NOS) and cyclooxygenase (COX) have been identified: constitutive versus inducible. In general, the constitutive form functions in housekeeping and physiologic roles whereas the inducible form is up-regulated by mitogenic or inflammatory stimuli and is responsible for pathophysiological responses. The cross talk between the COX and NOS pathways was initially reported in 1993 and since then, numerous studies have been undertaken to delineate the functional consequences of this interaction as well as the potential mechanism by which each pathway interacts. This review will focus in particular on recent advances in this field that extend our understanding of these two pathways under various systems.
一氧化氮（NO）和前列腺素的生物合成有许多相似之处。已经确定了两种主要形式的一氧化氮合酶（NOS）和环氧化酶（COX）：组成型与诱导型。一般来说，组成型形式在管家和生理作用中起作用，而诱导型形式则由有丝分裂原或炎症刺激物上调，负责病理生理反应。COX 和 NOS 途径之间的串扰最初于 1993 年报道，此后，进行了许多研究以阐明这种相互作用的功能后果以及每种途径相互作用的潜在机制。本综述将特别关注该领域的最新进展，这些进展扩展了我们对这两种途径在各种系统下的理解。
