Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Hum Pathol. 2012 Feb;43(2):307-11. doi: 10.1016/j.humpath.2011.04.028. Epub 2011 Aug 4.
Indeterminate cell tumor is an extremely rare neoplasm that mainly occurs in the skin. We report a case of indeterminate cell tumor arising from the spleen, a previously unreported site for indeterminate cell tumor. Histologically, the tumor showed nests, nodules, and sheets of large polygonal cells with mostly oval nuclei; open chromatin; variable nucleoli; and abundant, eosinophilic cytoplasm. Some cells possessed irregularly convoluted nuclei with nuclear grooves and granular cytoplasm, suggestive of Langerhans cells. Immunohistochemically, the tumor cells were diffusely positive for S-100 and CD1a and negative for Langerin. No Birbeck granules were found by electron microscopy. Clinical and radiologic examination showed no other organomegaly or lymphadenopathy. A diagnosis of primary indeterminate cell tumor of the spleen was rendered. To the best of our knowledge, this is the first indeterminate cell tumor reported in the spleen. Biologic insights into dendritic cells in the spleen and the pertinent literature on these entities are reviewed.
未确定细胞肿瘤是一种极其罕见的肿瘤，主要发生在皮肤。我们报告了一例发生在脾脏的未确定细胞肿瘤，这是以前未报道过的未确定细胞肿瘤发生部位。组织学上，肿瘤呈巢状、结节状和片状，由大多呈卵圆形核的大多边形细胞组成；开放染色质；大小不一的核仁；以及丰富的嗜酸性细胞质。一些细胞具有不规则卷曲的核和颗粒状细胞质，提示朗格汉斯细胞。免疫组化染色显示肿瘤细胞弥漫性表达 S-100 和 CD1a，而不表达 Langerin。电子显微镜未发现伯贝克颗粒。临床和影像学检查未发现其他器官肿大或淋巴结病。诊断为脾脏原发性未确定细胞肿瘤。据我们所知，这是首例报道的脾脏未确定细胞肿瘤。综述了脾脏树突状细胞的生物学特征及相关文献。
