Iqbal Shaikh B, Chittal Abhinandan R, Rao Shiavax J, Lakra Pallavi, Bhansali Deepty, Pyrgos George
Department of Medicine, MedStar Health Internal Medicine Residency Program, Baltimore, MD, USA.
Clinical and Laboratory Pathology, Anatomic Pathology, MedStar Health, Baltimore, MD, USA.
J Surg Case Rep. 2022 Jun 7;2022(6):rjac211. doi: 10.1093/jscr/rjac211. eCollection 2022 Jun.
Spontaneous splenic rupture is a rare and life-threatening phenomenon, usually associated with an underlying infectious, inflammatory, hematological, neoplastic or rheumatologic condition. Indeterminate cell tumor is a rare neoplastic dendritic cell disorder that is poorly understood but shares immunophenotypic markers for Langerhans cells without Birbeck granules. A 73-year-old man presented with upper abdominal pain after an unwitnessed fall. Computed tomography angiography showed splenomegaly and a large ruptured splenic subcapsular hematoma. Intraoperative findings from an emergency laparotomy revealed a large hemoperitoneum and a ruptured spleen. Microscopic sections identified numerous, mostly poorly formed, small nodules classified as a proliferation of indeterminate dendritic cell tumors.
自发性脾破裂是一种罕见且危及生命的现象，通常与潜在的感染、炎症、血液学、肿瘤或风湿性疾病相关。不确定细胞肿瘤是一种罕见的肿瘤性树突状细胞疾病，目前了解较少，但具有朗格汉斯细胞的免疫表型标记物，且无伯贝克颗粒。一名73岁男性在未被目睹的跌倒后出现上腹部疼痛。计算机断层血管造影显示脾肿大和巨大的脾包膜下破裂血肿。急诊剖腹手术的术中发现显示有大量腹腔积血和脾脏破裂。显微镜切片发现大量大多形态不佳的小结节，分类为不确定树突状细胞瘤的增殖。
