Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232–2551, USA.
Epilepsy Behav. 2011 Oct;22(2):398-400. doi: 10.1016/j.yebeh.2011.06.032. Epub 2011 Aug 5.
Vagus nerve stimulation is considered to be a safe and effective adjunctive therapy for patients with drug-resistant epilepsy. Contrary to some antiepileptic drugs, vagus nerve stimulation is not known to precipitate or aggravate new or preexisting seizures. We describe the emergence of a new type of disabling, recurrent partial seizure immediately after initiation of vagus nerve stimulation in a 51-year-old man with a known history of refractory partial epilepsy. Discontinuation of vagus nerve stimulation therapy and multiple antiepileptic drug interventions were required to abort these unexpected new seizures. We conclude that vagus nerve stimulation may induce paradoxical seizures, similarly to some antiepileptic drugs.
迷走神经刺激被认为是一种安全有效的辅助治疗方法，适用于耐药性癫痫患者。与某些抗癫痫药物不同，迷走神经刺激不会引发或加重新的或先前存在的癫痫发作。我们描述了一名 51 岁男性在开始迷走神经刺激后立即出现一种新的、使人丧失能力的、复发性部分性癫痫发作的情况，该患者已知患有难治性部分性癫痫。需要停止迷走神经刺激治疗和多种抗癫痫药物干预，以终止这些意外的新发作。我们的结论是，迷走神经刺激可能会像某些抗癫痫药物一样引起矛盾性癫痫发作。
