自体脂肪移植在乳腺癌中的安全性：来自干细胞生物学的启示。
The safety of autologous fat transfer in breast cancer: lessons from stem cell biology.
机构信息
Department of Plastic and Reconstructive Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, United Kingdom.
出版信息
J Plast Reconstr Aesthet Surg. 2012 Mar;65(3):283-8. doi: 10.1016/j.bjps.2011.07.017. Epub 2011 Aug 4.
Abstract
Autologous fat grafting is versatile tool in plastic surgery and is increasing used for reconstruction following breast conserving surgery for breast cancer. Part of the reconstructive qualities of the transferred fat may be due to the presence of adipose derived mesenchymal stem cells (ADMSC) playing an angiogenic and an adipogenic role. In this context it must be considered if autologously engrafted fat tissue could contribute to carcinogenesis following breast conserving surgery. In this article we review the current stem cell biology evidence on engraftment, transdifferentiation and potential carcinogenic contribution in the breast and other solid organ stem cell niches in an attempt to highlight possible areas of concern.
摘要
自体脂肪移植是整形手术中一种多用途的工具，越来越多地用于乳腺癌保乳手术后的重建。转移脂肪的部分重建特性可能是由于存在脂肪来源的间充质干细胞（ADMSC），发挥血管生成和脂肪生成作用。在这种情况下，必须考虑自体移植的脂肪组织是否会导致保乳手术后的癌变。本文综述了目前关于干细胞生物学的证据，包括在乳腺和其他实体器官干细胞龛中的植入、转分化和潜在致癌作用，试图突出可能令人关注的领域。
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Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant.同种异体干细胞移植后，人食管 Barrett 腺癌、相关成肌纤维细胞和内皮细胞可来源于骨髓来源的细胞。
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