Department of Plastic and Reconstructive Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, United Kingdom.
J Plast Reconstr Aesthet Surg. 2012 Mar;65(3):283-8. doi: 10.1016/j.bjps.2011.07.017. Epub 2011 Aug 4.
Autologous fat grafting is versatile tool in plastic surgery and is increasing used for reconstruction following breast conserving surgery for breast cancer. Part of the reconstructive qualities of the transferred fat may be due to the presence of adipose derived mesenchymal stem cells (ADMSC) playing an angiogenic and an adipogenic role. In this context it must be considered if autologously engrafted fat tissue could contribute to carcinogenesis following breast conserving surgery. In this article we review the current stem cell biology evidence on engraftment, transdifferentiation and potential carcinogenic contribution in the breast and other solid organ stem cell niches in an attempt to highlight possible areas of concern.
自体脂肪移植是整形手术中一种多用途的工具，越来越多地用于乳腺癌保乳手术后的重建。转移脂肪的部分重建特性可能是由于存在脂肪来源的间充质干细胞（ADMSC），发挥血管生成和脂肪生成作用。在这种情况下，必须考虑自体移植的脂肪组织是否会导致保乳手术后的癌变。本文综述了目前关于干细胞生物学的证据，包括在乳腺和其他实体器官干细胞龛中的植入、转分化和潜在致癌作用，试图突出可能令人关注的领域。
