INSERM, U957, Nantes, France.
PLoS One. 2010 Jun 8;5(6):e10999. doi: 10.1371/journal.pone.0010999.
Osteosarcoma is the most common malignant primary bone tumour in young adult treated by neo adjuvant chemotherapy, surgical tumor removal and adjuvant multidrug chemotherapy. For correction of soft tissue defect consecutive to surgery and/or tumor treatment, autologous fat graft has been proposed in plastic and reconstructive surgery.
We report here a case of a late local recurrence of osteosarcoma which occurred 13 years after the initial pathology and 18 months after a lipofilling procedure. Because such recurrence was highly unexpected, we investigated the possible relationship of tumor growth with fat injections and with mesenchymal stem/stromal cell like cells which are largely found in fatty tissue. Results obtained in osteosarcoma pre-clinical models show that fat grafts or progenitor cells promoted tumor growth.
These observations and results raise the question of whether autologous fat grafting is a safe reconstructive procedure in a known post neoplasic context.
骨肉瘤是青少年中最常见的恶性原发性骨肿瘤，采用新辅助化疗、手术肿瘤切除和辅助多药化疗进行治疗。为了纠正手术和/或肿瘤治疗后软组织的缺陷，自体脂肪移植已在整形和重建外科中被提出。
我们在此报告一例骨肉瘤的晚期局部复发病例，该病例在初次病理学检查后 13 年和脂肪填充术后 18 个月发生。由于这种复发是高度意外的，我们研究了肿瘤生长与脂肪注射之间以及与脂肪组织中大量存在的间充质干细胞/基质细胞样细胞之间的可能关系。骨肉瘤临床前模型的研究结果表明，脂肪移植或祖细胞促进了肿瘤生长。
这些观察结果和结果提出了一个问题，即自体脂肪移植在已知的肿瘤后背景下是否是一种安全的重建手术。
