心肌炎症中的巨噬细胞多样性：综述。
Macrophage diversity in cardiac inflammation: a review.
机构信息
The Johns Hopkins University School of Medicine, Training Program in Immunology, USA.
出版信息
Immunobiology. 2012 May;217(5):468-75. doi: 10.1016/j.imbio.2011.06.009. Epub 2011 Jun 30.
Abstract
Cardiac inflammatory disease represents a significant public health burden, and interesting questions of immunopathologic science and clinical inquiry. Novel insights into the diverse programming and functions within the macrophage lineages in recent years have yielded a view of these cells as dynamic effectors and regulators of immunity, host defense, and inflammatory disease. In this review, we examine and discuss recent investigations into the complex participation of mononuclear phagocytic cells in the pathology of animal models of myocarditis.
摘要
心脏炎性疾病是一个重大的公共卫生负担，也是免疫病理科学和临床研究的有趣问题。近年来，人们对巨噬细胞谱系中的多样性编程和功能有了新的认识，这些细胞被视为免疫、宿主防御和炎症性疾病的动态效应物和调节剂。在这篇综述中，我们检查和讨论了单核吞噬细胞在心肌炎动物模型病理中的复杂参与的最新研究。
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