Frith P, Burge S M, Millard P R, Wojnarowska F
Department of Ophthalmology, Oxford Eye Hospital.
Br J Ophthalmol. 1990 Mar;74(3):163-7. doi: 10.1136/bjo.74.3.163.
A selected group of 18 patients with systemic lupus erythematosus (SLE) and 30 patients with chronic cutaneous lupus erythematosus (CCLE) showed an unexpectedly high incidence of problems involving the globe or eyelids. Five SLE patients had recurrent episcleritis, two CCLE patients had lower tarsal plaques, and two further CCLE patients had erosion of the lower lid margins associated with conjunctival scarring and symblepharon. This association has not previously been reported. There was an unexpectedly high incidence of deposition of immunoreactants in a linear pattern at the basement membrane zone in normal bulbar conjunctiva, which occurred in both SLE (42%) and CCLE (50%). The significance of these findings is discussed. We believe surface ocular problems in lupus erythematosus to be under-reported and that direct immunofluorescence of bulbar conjunctival biopsy might be helpful in diagnosis.
一组经挑选的18例系统性红斑狼疮（SLE）患者和30例慢性皮肤型红斑狼疮（CCLE）患者出现涉及眼球或眼睑问题的发生率意外地高。5例SLE患者有复发性巩膜炎，2例CCLE患者有下睑板斑块，另有2例CCLE患者有下睑缘糜烂伴结膜瘢痕形成和睑球粘连。这种关联此前未见报道。在正常球结膜的基底膜区出现免疫反应物呈线性沉积的发生率意外地高，在SLE患者中占42%，在CCLE患者中占50%。对这些发现的意义进行了讨论。我们认为红斑狼疮的眼部表面问题未得到充分报告，球结膜活检的直接免疫荧光检查可能有助于诊断。
