Liepert D J, Douglas M J, McMorland G H, Gambling D R, Kim J H, Ross P L
Department of Anaesthesia, University of British Columbia, Vancouver, Canada.
Can J Anaesth. 1990 Apr;37(3):333-6. doi: 10.1007/BF03005585.
Lidocaine can be prepared in a variety of ways which may affect the characteristics of neural blockade achieved. Experimental evidence is equivocal as to the clinical impact of the use of different lidocaine preparations. A randomized, double-blind study was performed to investigate the differences in epidural anaesthesia for Caesarean section using three different lidocaine solutions: lidocaine CO2, two per cent lidocaine and two per cent lidocaine with its pH adjusted by the addition of bicarbonate. No differences were found among the groups in time of onset of neural blockade, quality or duration of neural blockade, time to delivery of the infant or volume of anaesthetic solution injected into the epidural space. A significant difference was found between the pH's of the solutions used. It is concluded that all three solutions are equally efficacious in epidural anaesthesia for Caesarean section.
利多卡因可以通过多种方式配制，这可能会影响所实现的神经阻滞特性。关于使用不同利多卡因制剂的临床影响，实验证据并不明确。进行了一项随机双盲研究，以调查使用三种不同利多卡因溶液进行剖宫产硬膜外麻醉的差异：二氧化碳利多卡因、2%利多卡因以及通过添加碳酸氢盐调节pH值的2%利多卡因。在神经阻滞起效时间、神经阻滞质量或持续时间、婴儿娩出时间或注入硬膜外腔的麻醉溶液体积方面，各组之间未发现差异。所使用溶液的pH值之间存在显著差异。得出的结论是，所有三种溶液在剖宫产硬膜外麻醉中同样有效。
