Children's Heart Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.
J Mater Sci Mater Med. 2011 Oct;22(10):2319-27. doi: 10.1007/s10856-011-4407-3. Epub 2011 Aug 6.
A bioabsorbable poly-p-dioxanone (PPDO) stent with a novel sliding-lock structure was fabricated to treat stenotic peripheral vessels. The sliding-lock PPDO stents have greater radial strength (107 kPa) than PPDO stents with conventional net-tube structure (32 kPa). The sliding-lock PPDO stents were implanted into the iliac arteries of pigs, and implantation success rate was 90% indicating the feasibility of this design. Additionally, we found that sliding-lock PPDO stents kept vessels patent, although by 3 and 6 months post implantation, luminal diameter decreased slightly due to intimal hyperplasia. At 1 month post implantation, the stents were sparsely covered with endothelial cells, and by 6 months, the stents were mostly absorbed and inflammatory reaction gradually decreased as the stents were absorbed. This study shows favorable mechanical strength, degradability and efficacy for the sliding-lock PPDO stents, and supports further research and development of this unique design of polymer stents for applications in vascular devices.
一种具有新型滑动锁定结构的可吸收性聚对二氧环己酮（PPDO）支架被制造出来，用于治疗狭窄的周围血管。滑动锁定 PPDO 支架的径向强度（107kPa）大于具有传统网筒结构的 PPDO 支架（32kPa）。滑动锁定 PPDO 支架被植入猪的髂动脉中，植入成功率为 90%，表明这种设计是可行的。此外，我们发现滑动锁定 PPDO 支架能够保持血管通畅，尽管在植入后 3 个月和 6 个月，由于内膜增生，管腔直径略有减小。在植入后 1 个月，支架上稀疏地覆盖着内皮细胞，而在 6 个月时，支架大部分已被吸收，随着支架的吸收，炎症反应逐渐减少。这项研究表明，滑动锁定 PPDO 支架具有良好的机械强度、可降解性和疗效，支持进一步研究和开发这种用于血管器械的独特聚合物支架设计。
