Life Sciences School of Hubei University, 368 Youyi Road, Wuchang, Wuhan 430062, China.
Immunogenetics. 2012 Jan;64(1):71-6. doi: 10.1007/s00251-011-0564-2. Epub 2011 Aug 6.
Fibroblast growth factor receptor 2 (FGFR2), a recently described risk factor for breast cancer, plays important roles in cell growth, invasiveness, motility, and angiogenesis. In attempt to investigate whether FGFR2 polymorphisms are associated with a risk of breast cancer in Chinese women of the Han nationality, we genotyped single-nucleotide polymorphisms (SNPs) of seven FGFR2 sites (rs2981582, rs17102287, rs17542768, rs10510097, rs11200012, rs3750817, rs2981578) in 816 women including 388 breast cancer patients and 428 healthy controls via the polymerase chain reaction single-strand conformation polymorphism procedure as well as sequence detection. Our results suggest that the A allele and AA genotype of SNP rs2981578 appear to be protective factors associated with breast cancer, while the CT genotype of SNP rs3750817 is a putative risk factor.
成纤维细胞生长因子受体 2（FGFR2）是最近被描述的乳腺癌风险因素，在细胞生长、侵袭性、运动性和血管生成中发挥重要作用。为了探讨 FGFR2 多态性是否与汉族中国女性乳腺癌的风险相关，我们通过聚合酶链反应单链构象多态性程序以及序列检测，对包括 388 例乳腺癌患者和 428 例健康对照在内的 816 名女性的 7 个 FGFR2 位点（rs2981582、rs17102287、rs17542768、rs10510097、rs11200012、rs3750817、rs2981578）的单核苷酸多态性（SNP）进行了基因分型。我们的结果表明，SNP rs2981578 的 A 等位基因和 AA 基因型似乎是与乳腺癌相关的保护因素，而 SNP rs3750817 的 CT 基因型则是一个可能的风险因素。
