埃塞俄比亚贡德尔大学综合专科医院女性中FGF受体2 rs2981578单核苷酸多态性与乳腺癌的关联

Association of FGF Receptor-2rs2981578 SNP with breast cancer in women at the University of Gondar Comprehensive Specialized Hospital, Ethiopia.

作者信息

Bogale Mihiret, Mengstie Tiget Ayelgn, Tadesse Ephrem, Dejenie Tadesse Asmamaw, Teferi Banchamlak, Siferih Melkamu, Takle Mulualem Nibret, Asefa Tseganesh, Dessie Gashaw, Tesfaye Winta, Kindie Endeshaw Asaye, Endale Hiwot Tezera, Tesfa Kibur Hunie, Ayelign Birhanu, Shibabaw Tewodros

机构信息

Department of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

PLoS One. 2025 Aug 1;20(8):e0327034. doi: 10.1371/journal.pone.0327034. eCollection 2025.

DOI:10.1371/journal.pone.0327034

PMID:40748883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12316240/

Abstract

INTRODUCTION

Fibroblast Growth Factor Receptor-2 single nucleotide polymorphisms are implicated in breast cancer development. However, there are inconsistencies and contradictions in the reports. The current study aimed to determine the association between Fibroblast Growth Factor Receptor-2 rs2981578 single nucleotide polymorphism and breast cancer among female breast cancer patients.

METHODS

A case-control study was conducted between August 2023 and April 2024 at University of Gondar Comprehensive Specialized Hospital, Gondar, and Northwest Ethiopia. Semi-structured was adapted to collect socio-demographic character and anthropometric measurement and 5 ml of blood were drawn from each randomly selected participant for molecular analysis. The data was entered into Epi-Data-7.2 and exported to SPSS-25. Binary logistic regression model was used to look into the association between various factors. Statistical significance was regarded as a p-value of < 0.05.

RESULTS

The Fibroblast Growth Factor Receptor-2 Single Nucleotide Polymorphisms rs2981578 AA genotype and A allele were more frequent in breast cancer patients than in controls (37% vs. 17% and 58% vs 42%; the chi-square p = 0.025 and p = 0.009, respectively). Individuals with the AA genotype and A allele were more prone to breast cancer (OR = 3.3; 95% CI: 1.293-8.538, and OR =1.88; 95% CI: 1.173, 3.029, respectively) than those with the wild type GG genotype. The risk allele correlated with the late TNM stage (COR = 3.41, 95% CI: 1.07-10.88).

CONCLUSION

The AA genotype and the A allele of the Fibroblast Growth Factor Receptor-2 Single Nucleotide Polymorphisms rs2981578 gene are more prevalent among women with breast cancer. They are correlated with increased susceptibility to breast cancer and a worsening of its stage.

摘要

引言

成纤维细胞生长因子受体2单核苷酸多态性与乳腺癌的发生有关。然而，报告中存在不一致和矛盾之处。本研究旨在确定女性乳腺癌患者中成纤维细胞生长因子受体2 rs2981578单核苷酸多态性与乳腺癌之间的关联。

方法

2023年8月至2024年4月在埃塞俄比亚西北部贡德尔的贡德尔大学综合专科医院进行了一项病例对照研究。采用半结构化方法收集社会人口学特征和人体测量数据，并从每个随机选择的参与者中抽取5毫升血液进行分子分析。数据录入Epi-Data-7.2并导出到SPSS-25。使用二元逻辑回归模型研究各种因素之间的关联。统计学显著性以p值<0.05为准。

结果

成纤维细胞生长因子受体2单核苷酸多态性rs2981578的AA基因型和A等位基因在乳腺癌患者中比在对照组中更常见（37%对17%，58%对42%；卡方检验p值分别为0.025和0. 009）。与野生型GG基因型相比，AA基因型和A等位基因的个体更易患乳腺癌（OR = 3.3；95% CI：1.293 - 8.538，以及OR = 1.88；95% CI：1.173，3.029）。风险等位基因与晚期TNM分期相关（COR = 3.41，95% CI：1.07 - 10.88）。