他莫昔芬联合辅酶Q10治疗特发性少弱精子症

[Tamoxifen combined with coenzyme Q10 for idiopathic oligoasthenospermia].

作者信息

Tang Kai-Fa, Xing Yao, Wu Chun-Yun, Liu Rui-Zhe, Wang Xin-Yang, Xing Jun-Ping

机构信息

Department of Urology, The First Affiliated Hospital, Medical College, Xi'an, Shaanxi 710061, China.

出版信息

Zhonghua Nan Ke Xue. 2011 Jul;17(7):615-8.

PMID:21823344

Abstract

OBJECTIVE

To investigate the effects of tamoxifen (TMX) combined with coenzyme Q10 (CoQ10) on idiopathic oligoasthenospermia.

METHODS

A total of 183 patients with idiopathic oligoasthenospermia were randomly divided into a TMX + CoQ10 group (n = 63), a TMX group (n = 61) and a CoQ10 group (n = 59). At the end of 3 and 6 months of treatment, semen analyses and hormone tests were performed, and the results were compared with those obtained before the treatment.

RESULTS

Compared with the pre-treatment results, the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) and sperm concentration were significantly elevated in the TMX + CoQ10 and TMX groups (P < 0.05), but showed no significant difference in the CoQ10 group (P > 0.05); sperm motility and morphologically normal sperm were increased significantly in the TMX + CoQ10 and CoQ10 groups (P < 0.05), and slightly in the TMX group but with no statistically significant difference (P > 0.05).

CONCLUSION

Tamoxifen combined with CoQ10 can significantly improve sperm concentration, motility and morphology in patients with idiopathic oligoasthenospermia.

摘要

目的

探讨他莫昔芬（TMX）联合辅酶Q10（CoQ10）对特发性少弱精子症的影响。

方法

将183例特发性少弱精子症患者随机分为TMX + CoQ10组（n = 63）、TMX组（n = 61）和CoQ10组（n = 59）。治疗3个月和6个月结束时，进行精液分析和激素检测，并将结果与治疗前获得的结果进行比较。

结果

与治疗前结果相比，TMX + CoQ10组和TMX组的促卵泡激素（FSH）、黄体生成素（LH）、睾酮（T）水平及精子浓度显著升高（P < 0.05），而CoQ10组无显著差异（P > 0.05）；TMX + CoQ10组和CoQ10组的精子活力和形态正常精子显著增加（P < 0.05），TMX组略有增加，但无统计学差异（P > 0.05）。