Mancini A, Raimondo S, Persano M, Di Segni C, Cammarano M, Gadotti G, Silvestrini A, Pontecorvi A, Meucci E
Division of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy.
Int J Endocrinol. 2013;2013:607939. doi: 10.1155/2013/607939. Epub 2013 Nov 20.
Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.
在针对特发性男性不育症提出的治疗方法中，抗雌激素药物，如他莫昔芬，可能发挥作用。另一方面，氧化应激是一种公认的对精子功能有有害影响的机制。在回顾了关于雌激素在调节两性抗氧化系统中的作用以及不同体内和体外模型的文献后，我们也基于个人数据表明，他莫昔芬治疗可能通过增加精液中的抗氧化剂而发挥作用。
