Patel Kanika, Singh Gireesh Kumar, Patel Dinesh Kumar
G.L.A Institute of Pharmaceutical Research, Mathura, India.
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, India.
Chin J Integr Med. 2018 Jul;24(7):551-560. doi: 10.1007/s11655-014-1960-x. Epub 2014 Dec 10.
Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.
黄酮类化合物是一类广泛分布的具有苯并吡喃核的植物化学物质，已被描述的不同黄酮类化合物超过4000种，并被分类为黄酮醇、黄酮、黄烷酮、异黄酮、儿茶素和花青素。黄酮类化合物天然存在于水果、蔬菜、坚果以及咖啡、茶和红酒等饮料中，也存在于药草中。黄酮类化合物决定了植物各部分的不同颜色，是人类饮食的重要组成部分。黄酮类化合物具有不同的药理活性，如抗氧化、抗过敏、抗菌、抗炎、抗诱变和抗癌活性。柚皮素属于黄烷酮类，主要存在于水果（葡萄柚和橙子）和蔬菜中。在药理学上，它具有抗癌、抗诱变、抗炎、抗氧化、抗增殖和抗动脉粥样硬化活性。柚皮素用于治疗骨质疏松症、癌症和心血管疾病，并具有降血脂和胰岛素样特性。在本综述中，介绍了柚皮素详细的药理学和分析方面的内容，揭示了其令人印象深刻的药理学特征以及未来在治疗不同类型疾病方面可能的用途。本通讯中提供的信息将成为开发治疗各种疾病有效药物的重要来源。
