van der Gaag R, Vernimmen R, Fiebelkorn N, van Dierendonck M C, Kijlstra A
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
Int Ophthalmol. 1990 Jan;14(1):25-30. doi: 10.1007/BF00131165.
Graves' ophthalmopathy is thought to be an autoimmune disease. Whether this disease is organ specific or one of the manifestations of the closely linked Graves' thyroid disease is still a matter of speculation. Many papers describe autoimmunity to orbital antigens, in particular to extraocular muscles, in patients with Graves' ophthalmopathy. In this paper we have tried to give an overview of the evidence for circulating antibodies against extraocular muscle antigens and to discuss their significance in relation to the immunopathogenesis of the disease.
格雷夫斯眼病被认为是一种自身免疫性疾病。这种疾病是器官特异性的，还是密切相关的格雷夫斯甲状腺疾病的表现之一，仍然存在争议。许多论文描述了格雷夫斯眼病患者针对眼眶抗原，特别是眼外肌的自身免疫。在本文中，我们试图概述针对眼外肌抗原的循环抗体的证据，并讨论它们在该疾病免疫发病机制中的意义。
