钙化性主动脉瓣疾病的动物模型。
Animal models of calcific aortic valve disease.
作者信息
Sider Krista L, Blaser Mark C, Simmons Craig A
机构信息
Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, Canada M5S 3G9.
出版信息
Int J Inflam. 2011;2011:364310. doi: 10.4061/2011/364310. Epub 2011 Aug 2.
Abstract
Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the utility of existing models. In this paper, we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for priority CAVD research areas, and provide recommendations for future animal model studies of CAVD.
摘要
钙化性主动脉瓣疾病（CAVD），曾被认为是一种退行性疾病，现在被认为是一个活跃的病理生物学过程，慢性炎症已成为主要的，甚至可能是驱动性因素。然而，CAVD病理生物学机制的许多细节仍有待描述，并且需要确定治疗CAVD的新方法。为此，动物模型正成为至关重要的工具，这得益于新模型的出现以及对现有模型效用的更好理解。在本文中，我们总结并批判性地评估了当前CAVD的小型和大型动物模型，讨论了动物模型在CAVD优先研究领域的效用，并为未来CAVD动物模型研究提供建议。
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