1,3-环己二酮的多米诺烷基化/氧杂-Michael 反应：控制 C/O 化学选择性以得到四氢苯并呋喃酮。
Domino alkylation/oxa-Michael of 1,3-cyclohexanediones: steering the C/O-chemoselectivity to reach tetrahydrobenzofuranones.
机构信息
Laboratoire des Fonctions Azotées et Oxygénées Complexes de l'IRCOF, CNRS UMR 6014 & FR 3038, Université de Rouen, Mont Saint-Aignan, 76130, France.
出版信息
Org Biomol Chem. 2011 Oct 7;9(19):6509-12. doi: 10.1039/c1ob05923h. Epub 2011 Aug 8.
PMID:21826296
Abstract
An unprecedented domino synthesis of tetrahydrobenzofuran-4-ones is described implicating chemoselective alkylation of various 1,3-cyclohexanediones with bromocrotonate or crotonitrile followed by oxa-Michael cyclization. Further transformations of this core to reach molecular diversity are also presented.
摘要
描述了一种前所未有的四氢苯并呋喃-4-酮的级联合成，涉及各种 1,3-环己二酮与溴代巴豆酸酯或巴豆腈的选择性烷基化，随后进行氧杂-Michael 环化。还介绍了这种核心结构进一步转化以达到分子多样性的方法。
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