Roemer R B
Department of Radiation Oncology, University of Arizona, Tucson 85721.
Int J Hyperthermia. 1990 Mar-Apr;6(2):421-30. doi: 10.3109/02656739009141148.
Several investigators have attempted to utilize either transient 'thermal washout' and/or steady-state temperature data from standard hyperthermia thermometry to obtain information regarding both tumour and normal tissue perfusions, and transient data to measure SAR distributions. This paper reviews that literature, presents a unified theoretical basis for all of the temporal 'perfusion' approaches, and shows that both the steady-state and the 'washout' techniques actually measure the same quantity, which is related to, but not equal to, the tissue perfusion. A new nomenclature for the quantity measured by these techniques is proposed, the local tissue cooling coefficient, a name which avoids any use of the term 'perfusion', in order to avoid unwarranted inferences regarding this quantity. The requirements for relating this quantity to the true tissue perfusion are presented, and possible applications of the local tissue cooling coefficient are reviewed. Finally, the techniques used by various investigators for normalizing SAR data are summarized and discussed, and a standard approach suggested.
几位研究人员试图利用标准热疗温度测量中的瞬态“热清除”和/或稳态温度数据来获取有关肿瘤和正常组织灌注的信息，并利用瞬态数据来测量比吸收率（SAR）分布。本文回顾了该文献，为所有时间“灌注”方法提供了统一的理论基础，并表明稳态和“清除”技术实际上测量的是同一个量，该量与组织灌注有关，但并不等于组织灌注。本文提出了这些技术所测量的量的新术语——局部组织冷却系数，这个名称避免了使用“灌注”一词，以免对该量做出无端推断。本文阐述了将该量与真实组织灌注相关联的要求，并回顾了局部组织冷却系数的可能应用。最后，总结并讨论了不同研究人员用于标准化SAR数据的技术，并提出了一种标准方法。
