诱导多能干细胞 (iPSCs) 与神经疾病建模：进展与前景。
Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.
机构信息
Laboratory of Genetics (LOG-G), The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Hum Mol Genet. 2011 Oct 15;20(R2):R109-15. doi: 10.1093/hmg/ddr336. Epub 2011 Aug 9.
Abstract
The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.
摘要
从神经障碍患者中系统性地生成神经元，可深入了解疾病的病理、进展和机制。本综述将讨论使用诱导多能干细胞（iPSC）对神经退行性和神经发育性疾病进行建模的最新进展，并重点介绍该领域当前面临的一些挑战。与之前用于研究脑部疾病的其他技术相结合，iPSC 建模有望在以下几个方面影响现代医学：早期诊断、药物开发和有效治疗。
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