Lequesne M
Department of Rheumatology, Leopold Bellan Hospital, Paris, France.
J Rheumatol Suppl. 1990 Feb;20:25-8.
The characteristics required of tests used in trials of nonsteroidal antiinflammatory drugs in patients with inflammatory rheumatic diseases in order for such tests to provide meaningful results are reviewed. Those tests most widely used in trials of patients with rheumatoid arthritis or ankylosing spondylitis are assessed, and the ability of such tests to discriminate among the treatment effects of different agents is considered. Finally, several statistical and procedural issues important to clinical trial methodology are discussed.
本文回顾了在炎性风湿性疾病患者中进行非甾体抗炎药试验时，为使试验所用检测方法能提供有意义结果所需具备的特征。评估了在类风湿关节炎或强直性脊柱炎患者试验中最广泛使用的那些检测方法，并考量了这些检测方法区分不同药物治疗效果的能力。最后，讨论了对临床试验方法学很重要的几个统计学和程序问题。
