a College of Chemistry, Sichuan University , Chengdu , China.
b Research Center of Analytical Instrumentation, Key Laboratory of Bio-resource and Eco-environment, Ministry of Education, College of Life Sciences, Sichuan University , Chengdu , China.
Crit Rev Anal Chem. 2016 Jul 3;46(4):291-304. doi: 10.1080/10408347.2015.1055550. Epub 2015 Nov 3.
Breath analysis is a noninvasive diagnostic method that profiles a person's physical state by volatile organic compounds in the breath. It has huge potential in the field of disease diagnosis. In order to offer opportunities for practical applications, various GC-based techniques have been investigated for on-line breath analysis since GC is the most preferred technique for mixed gas separation. This article reviews the development of breath analysis and GC-based techniques in basic breath research, involving sampling methods, preconcentration methods, conventional GC-based techniques, and newly developed GC techniques for breath analysis. The combination of GC and newly developed detection techniques takes advantages of the virtues of each. In addition, portable GC or micro GC are poised to become field GC-based techniques in breath analysis. Challenges faced in GC-based techniques for breath analysis are discussed candidly. Effective cooperation of experts from different fields is urgent to promote the development of breath analysis.
呼气分析是一种非侵入性的诊断方法，通过呼吸中的挥发性有机化合物来描绘人体的生理状态。它在疾病诊断领域具有巨大的潜力。为了提供实际应用的机会，已经研究了各种基于 GC 的技术用于在线呼气分析，因为 GC 是混合气体分离的首选技术。本文综述了基础呼气研究中呼气分析和基于 GC 的技术的发展，涉及采样方法、预浓缩方法、常规 GC 技术和新开发的用于呼气分析的 GC 技术。GC 与新开发的检测技术的结合利用了各自的优点。此外，便携式 GC 或微 GC 有望成为呼气分析中的现场 GC 技术。本文还坦诚地讨论了基于 GC 的呼气分析技术所面临的挑战。急需不同领域的专家有效合作，以促进呼气分析的发展。
