Righettoni Marco, Ragnoni Alessandro, Güntner Andreas T, Loccioni Claudio, Pratsinis Sotiris E, Risby Terence H
Particle Technology Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, CH-8092 Zurich, Switzerland.
J Breath Res. 2015 Oct 15;9(4):047101. doi: 10.1088/1752-7155/9/4/047101.
Breath analysis has the potential to detect and monitor diseases as well as to reduce the corresponding medical costs while improving the quality of a patient's life. Herein, a portable prototype, consisting of a commercial breath sampler modified to work as a platform for solid-state gas sensors was developed. The sensor is placed close to the mouth (<10 cm) and minimizes the mouth-to-sensor path to avoid contamination and dilution of the target breath marker. Additionally with an appropriate cooling concept, even high sensor operating temperatures (e.g. 350 °C) could be used. Controlled sampling is crucial for accurate repeatable analysis of the human breath and these concerns have been addressed by this novel prototype. The device helps a subject control their exhaled flow rate which increases reproducibility of intra-subject breath samples. The operation of this flame-made selective chemo-resistive gas sensor is demonstrated by the detection of breath acetone.
呼吸分析有潜力检测和监测疾病，同时降低相应的医疗成本并提高患者的生活质量。在此，我们开发了一种便携式原型，它由一个经过改装的商用呼吸采样器组成，可作为固态气体传感器的平台。传感器放置在靠近口腔的位置（<10厘米），并将口腔到传感器的路径减至最短，以避免目标呼吸标志物受到污染和稀释。此外，通过适当的冷却概念，甚至可以使用较高的传感器工作温度（例如350°C）。控制采样对于准确、可重复地分析人体呼吸至关重要，而这种新型原型已经解决了这些问题。该设备有助于受试者控制其呼出流速，从而提高受试者内呼吸样本的可重复性。通过检测呼吸丙酮来证明这种火焰制造的选择性化学电阻气体传感器的操作。
