• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

先天免疫细胞因子反应降低与呼吸道合胞病毒和人类鼻病毒毛细支气管炎患儿的疾病严重程度相关。

Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis.

机构信息

Division of Pediatric Infectious Diseases, UT Southwestern Medical Center, Dallas, TX, USA.

出版信息

Pediatr Infect Dis J. 2012 Jan;31(1):86-9. doi: 10.1097/INF.0b013e31822dc8c1.

DOI:10.1097/INF.0b013e31822dc8c1
PMID:21829141
Abstract

The immunopathogenesis of respiratory syncytial virus (RSV) and human rhinovirus lower respiratory tract infections in children remains to be defined. We measured nasal wash concentrations of 29 cytokines in infants with RSV or human rhinovirus lower respiratory tract infections. Concentrations of interferon-γ in RSV and innate immunity cytokines in both infections inversely correlated with disease severity.

摘要

呼吸道合胞病毒（RSV）和人类鼻病毒下呼吸道感染的免疫发病机制仍有待确定。我们测量了患有 RSV 或人类鼻病毒下呼吸道感染的婴儿鼻洗液中 29 种细胞因子的浓度。RSV 中干扰素-γ的浓度和两种感染中先天免疫细胞因子的浓度与疾病严重程度呈负相关。

相似文献

1
Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis.先天免疫细胞因子反应降低与呼吸道合胞病毒和人类鼻病毒毛细支气管炎患儿的疾病严重程度相关。
Pediatr Infect Dis J. 2012 Jan;31(1):86-9. doi: 10.1097/INF.0b013e31822dc8c1.
2
Equal virulence of rhinovirus and respiratory syncytial virus in infants hospitalized for lower respiratory tract infection.呼吸道合胞病毒和鼻病毒在住院治疗下呼吸道感染的婴儿中的毒力相当。
Pediatr Infect Dis J. 2012 Jan;31(1):84-6. doi: 10.1097/INF.0b013e31823345bf.
3
The role of TNF-alpha in eosinophilic inflammation associated with RSV bronchiolitis.TNF-α 在 RSV 细支气管炎相关嗜酸性粒细胞炎症中的作用。
Pediatr Allergy Immunol. 2010 May;21(3):474-9. doi: 10.1111/j.1399-3038.2009.00908.x. Epub 2009 Jan 14.
4
Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases.呼吸道合胞病毒和流感病毒感染：来自致命婴儿病例组织的观察结果
Pediatr Infect Dis J. 2008 Oct;27(10 Suppl):S92-6. doi: 10.1097/INF.0b013e318168b706.
5
Rhinovirus-induced bronchiolitis and asthma development.鼻病毒诱发的细支气管炎和哮喘发展。
Pediatr Allergy Immunol. 2011 Jun;22(4):350-5. doi: 10.1111/j.1399-3038.2011.01170.x.
6
Immunopathogenesis of respiratory syncytial virus bronchiolitis.呼吸道合胞病毒细支气管炎的免疫发病机制。
J Infect Dis. 2007 May 15;195(10):1532-40. doi: 10.1086/515575. Epub 2007 Apr 12.
7
Effect of dexamethasone on respiratory syncytial virus-induced lung inflammation in children: results of a randomized, placebo controlled clinical trial.地塞米松对儿童呼吸道合胞病毒诱导的肺部炎症的影响：一项随机、安慰剂对照临床试验的结果
Pediatr Allergy Immunol. 2009 Aug;20(5):477-85. doi: 10.1111/j.1399-3038.2009.00852.x. Epub 2009 Apr 24.
8
Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants.呼吸道合胞病毒、人类博卡病毒和鼻病毒毛细支气管炎在婴儿中。
Arch Dis Child. 2010 Jan;95(1):35-41. doi: 10.1136/adc.2008.153361. Epub 2009 Oct 11.
9
Low neonatal Toll-like receptor 4-mediated interleukin-10 production is associated with subsequent atopic dermatitis.新生儿低 Toll 样受体 4 介导的白细胞介素-10 产生与随后的特应性皮炎有关。
Clin Exp Allergy. 2012 Jan;42(1):66-75. doi: 10.1111/j.1365-2222.2011.03857.x. Epub 2011 Sep 20.
10
Innate immunity in respiratory syncytial virus bronchiolitis.呼吸道合胞病毒细支气管炎中的先天免疫
Exp Lung Res. 2007 Dec;33(10):543-7. doi: 10.1080/01902140701756711.

引用本文的文献

1
Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.SARS-CoV-2感染时黏膜和全身宿主反应的年龄相关差异。
Nat Commun. 2025 Mar 10;16(1):2383. doi: 10.1038/s41467-025-57655-3.
2
Comparison of characteristics and immune responses between paired human nasal and bronchial epithelial organoids.配对的人鼻和支气管上皮类器官之间的特征及免疫反应比较。
Cell Biosci. 2025 Feb 7;15(1):18. doi: 10.1186/s13578-024-01342-1.
3
Infants display reduced NK cell responses in RSV and increased inflammatory responses in SARS-CoV-2 infections.
婴儿在呼吸道合胞病毒（RSV）感染中自然杀伤（NK）细胞反应降低，在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染中炎症反应增加。
Res Sq. 2025 Jan 13:rs.3.rs-5640872. doi: 10.21203/rs.3.rs-5640872/v1.
4
Infant-derived human nasal organoids exhibit relatively increased susceptibility, epithelial responses, and cytotoxicity during RSV infection.源自婴儿的人鼻类器官在呼吸道合胞病毒（RSV）感染期间表现出相对更高的易感性、上皮反应和细胞毒性。
J Infect. 2024 Dec;89(6):106305. doi: 10.1016/j.jinf.2024.106305. Epub 2024 Oct 9.
5
Viral etiology of febrile respiratory syndrome among patients in Liaoning Province, China.中国辽宁省发热呼吸道综合征患者的病毒病因。
BMC Infect Dis. 2024 Sep 27;24(1):1060. doi: 10.1186/s12879-024-09956-z.
6
Disease Severity and Cytokine Expression in the Rhinovirus-Induced First Wheezing Episode.病毒诱导的首次喘息发作的疾病严重程度和细胞因子表达。
Viruses. 2024 Jun 7;16(6):924. doi: 10.3390/v16060924.
7
Prevalence of human respiratory pathogens and associated mucosal cytokine levels in young children and adults: a cross-sectional observational study in the Netherlands during the winter of 2012/2013.2012/2013 年冬季荷兰一项横断面观察性研究：儿童和成人人群中人类呼吸道病原体的流行情况及其相关黏膜细胞因子水平。
Pathog Dis. 2024 Feb 7;82. doi: 10.1093/femspd/ftae010.
8
Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.在呼吸道合胞病毒（RSV）感染期间，小儿人类鼻类器官比成人表现出更高的易感性、上皮反应和细胞毒性。
bioRxiv. 2024 Feb 1:2024.02.01.578466. doi: 10.1101/2024.02.01.578466.
9
Efficient symptomatic treatment and viral load reduction for children with influenza virus infection by nasal-spraying Bacillus spore probiotics.鼻喷芽孢益生菌治疗儿童流感病毒感染的高效对症治疗及病毒载量降低。
Sci Rep. 2023 Sep 8;13(1):14789. doi: 10.1038/s41598-023-41763-5.
10
Type III Interferons, Viral Loads, Age, and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.III 型干扰素、病毒载量、年龄与呼吸道合胞病毒感染幼儿疾病严重程度的关系。
J Infect Dis. 2022 Dec 28;227(1):61-70. doi: 10.1093/infdis/jiac404.