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中国辽宁省发热呼吸道综合征患者的病毒病因。

Viral etiology of febrile respiratory syndrome among patients in Liaoning Province, China.

机构信息

Liaoning Provincial Center for Disease Control and Prevention, Shenyang, Liaoning, China.

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, China.

出版信息

BMC Infect Dis. 2024 Sep 27;24(1):1060. doi: 10.1186/s12879-024-09956-z.

DOI:10.1186/s12879-024-09956-z
PMID:39333919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11429093/
Abstract

BACKGROUND

Febrile respiratory syndrome (FRS) is often associated with viral infections. The aim of this study was to identify the viral pathogens responsible for FRS in Liaoning Province, China.

METHODS

We tested eight respiratory viruses, namely, influenza virus (IFV), rhinovirus (RV), human adenovirus (HAdV), human bocavirus (HBoV), human parainfluenza virus (HPIV), human coronavirus (HCoV), respiratory syncytial virus (RSV), and human metapneumovirus (HMPV), using reverse transcription-polymerase chain reaction (RT-PCR). Statistical analyses were performed using SPSS version 25.0, and the data were plotted using RStudio 4.2.1 software.

RESULTS

IFV was the most frequently identified pathogen, followed by RV, HAdV, HBoV, HPIV, HCoV, RSV, and HMPV. RSV/HBoV coinfection occurred most frequently among the mixed cases. The rate of respiratory virus detection was highest in children under one year of age and decreased significantly with age. Seasonal trends showed a peak in virus detection during the winter months.

CONCLUSIONS

IFV is the leading cause of FRS in Liaoning Province, China, with single-virus infections prevailing over coinfections. Observations indicate a differential virus detection rate across age groups and seasons, highlighting the need for focused preventive strategies to mitigate the transmission of respiratory viruses, particularly among susceptible populations in the colder season.

摘要

背景

发热性呼吸道综合征（FRS）常与病毒感染有关。本研究旨在确定导致中国辽宁省 FRS 的病毒病原体。

方法

我们使用逆转录-聚合酶链反应（RT-PCR）检测了 8 种呼吸道病毒，包括流感病毒（IFV）、鼻病毒（RV）、人腺病毒（HAdV）、人博卡病毒（HBoV）、人副流感病毒（HPIV）、人冠状病毒（HCoV）、呼吸道合胞病毒（RSV）和人偏肺病毒（HMPV）。使用 SPSS 版本 25.0 进行统计分析，使用 RStudio 4.2.1 软件绘图。

结果

IFV 是最常被识别的病原体，其次是 RV、HAdV、HBoV、HPIV、HCoV、RSV 和 HMPV。混合感染中以 RSV/HBoV 共感染最为常见。呼吸道病毒检测率在 1 岁以下儿童中最高，随年龄增长显著下降。季节趋势显示病毒检测在冬季达到高峰。

结论

IFV 是中国辽宁省 FRS 的主要病原体，单病毒感染超过了共感染。观察结果表明，不同年龄组和季节的病毒检测率存在差异，这突出表明需要制定有针对性的预防策略，以减轻呼吸道病毒的传播，特别是在寒冷季节对易感人群的传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/fe803ce37513/12879_2024_9956_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/848770902bd6/12879_2024_9956_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/8bf778901c3d/12879_2024_9956_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/e809f98fdc11/12879_2024_9956_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/fe803ce37513/12879_2024_9956_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/848770902bd6/12879_2024_9956_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/8bf778901c3d/12879_2024_9956_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/e809f98fdc11/12879_2024_9956_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a43/11429093/fe803ce37513/12879_2024_9956_Fig4_HTML.jpg

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