Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, United States of America.
PLoS One. 2011;6(8):e22368. doi: 10.1371/journal.pone.0022368. Epub 2011 Aug 4.
The aim of this event-related functional magnetic resonance imaging (fMRI) study was to test whether the right middle frontal gyrus (MFG) and middle temporal gyrus (MTG) would show differential sensitivity to the effect of prime-target association strength on repetition priming. In the experimental condition (RP), the target occurred after repetitive presentation of the prime within an oddball design. In the control condition (CTR), the target followed a single presentation of the prime with equal probability of the target as in RP. To manipulate semantic overlap between the prime and the target both conditions (RP and CTR) employed either the onomatopoeia "oink" as the prime and the referent "pig" as the target (OP) or vice-versa (PO) since semantic overlap was previously shown to be greater in OP. The results showed that the left MTG was sensitive to release of adaptation while both the right MTG and MFG were sensitive to sequence regularity extraction and its verification. However, dissociated activity between OP and PO was revealed in RP only in the right MFG. Specifically, target "pig" (OP) and the physically equivalent target in CTR elicited comparable deactivations whereas target "oink" (PO) elicited less inhibited response in RP than in CTR. This interaction in the right MFG was explained by integrating these effects into a competition model between perceptual and conceptual effects in priming processing.
本事件相关功能磁共振成像（fMRI）研究旨在测试右侧额中回（MFG）和颞中回（MTG）是否对启动子-目标关联强度对重复启动的影响具有不同的敏感性。在实验条件（RP）下，目标在启动子重复呈现后在奇数设计中出现。在对照条件（CTR）下，目标跟随启动子的单次呈现，目标的出现概率与 RP 相同。为了操纵启动子和目标之间的语义重叠，两种条件（RP 和 CTR）都使用拟声词“oink”作为启动子和参考“pig”作为目标（OP）或反之亦然（PO），因为先前的研究表明 OP 中的语义重叠更大。结果表明，左 MTG 对适应释放敏感，而右 MTG 和 MFG 对序列规则提取及其验证敏感。然而，仅在 RP 中在右 MFG 中揭示了 OP 和 PO 之间的分离活动。具体来说，目标“pig”（OP）和 CTR 中物理等效的目标引起可比的去激活，而目标“oink”（PO）在 RP 中的抑制反应小于 CTR。右 MFG 中的这种相互作用通过将这些效应整合到启动处理中的感知和概念效应之间的竞争模型中进行了解释。
