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氮杂环卡宾在构建具有潜在生物活性的碳环和杂环骨架应用中的最新进展。

Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity.

作者信息

Li Mei-Mei, Chen Xiaozhen, Deng Yun, Lu Jun

机构信息

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

Chengdu Institute of Biology, Chinese Academy of Sciences Chengdu 610041 China.

出版信息

RSC Adv. 2021 Nov 26;11(60):38060-38078. doi: 10.1039/d1ra06155k. eCollection 2021 Nov 23.

DOI:10.1039/d1ra06155k
PMID:35498096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9044055/
Abstract

In recent years, N-heterocyclic carbenes (NHCs) have established themselves as a masterful and promising type of organocatalyst for the speedy construction of medicinally and biologically significant molecules from common and accessible small molecules. In particular, various cyclic scaffolds, including carbocycles and heterocycles, have been synthesized using NHCs cycloaddition reaction. An exhaustive review focused on the chemistry of NHCs in these cyclic molecules has yet to be reported. In this contribution, a general picture of the utilization of NHCs in constructing twelve kinds of bioactive cyclic skeletons is firstly presented. We provide a systematic and comprehensive overview from the perspective of cycloaddition reactions; moreover, the limitations, challenges, and future prospects were discussed.

摘要

近年来，N-杂环卡宾（NHCs）已成为一种巧妙且有前景的有机催化剂，可用于从常见且易得的小分子快速构建具有医学和生物学意义的分子。特别是，利用NHCs的环加成反应已合成了各种环状骨架，包括碳环和杂环。然而，尚未有一篇详尽的综述聚焦于这些环状分子中NHCs的化学性质。在本论文中，首先呈现了NHCs在构建十二种生物活性环状骨架中的应用概况。我们从环加成反应的角度提供了系统而全面的综述；此外，还讨论了其局限性、挑战和未来前景。

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