Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China).
Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10644-7. doi: 10.1002/anie.201305571. Epub 2013 Aug 13.
γ-Amination: The title reaction was developed to give the corresponding dihydropyridazinones in good yields with excellent enantioselectivities (see scheme; Mes=2,4,6-trimethylphenyl). The annulation reaction worked well for γ-aryl, γ-alkyl, or γ-alkenyl oxidized enals. Highly enantiopure tetrahydropyridazinones and γ-amino acid derivatives could be easily prepared by chemical transformations of the resulting dihydropyridazinones.
γ-氨化：该标题反应的发展是为了以良好的产率和优异的对映选择性得到相应的二氢哒嗪酮（见方案；Mes=2,4,6-三甲基苯基）。该环化反应对γ-芳基、γ-烷基或γ-烯基氧化醛的效果很好。通过对得到的二氢哒嗪酮进行化学转化，可以很容易地制备出高对映纯度的四氢哒嗪酮和γ-氨基酸衍生物。
