Ritz E, Hasslacher C, Tschöpe W
Department of Internal Medicine, Ruperto Karola University, Heidelberg, FRG.
Miner Electrolyte Metab. 1990;16(1):69-72.
It has commonly been assumed that the renal risk in type II diabetes is markedly lower than in type I diabetes since only approximately 5% of the former but 40% of the latter experience renal failure. Based on our observations in the diabetes outpatient department of the University of Heidelberg, we conclude that the cumulative risk of developing proteinuria for the nonproteinuric type II diabetic and the cumulative risk of developing renal failure for the proteinuric type II diabetic are comparable with the respective risks of the type I diabetic. This observation is noteworthy since there is no uncontroversial evidence of hyperfiltration in early type II diabetes. Type II diabetes may be an interesting model for testing the hyperfiltration theory.
人们通常认为，II型糖尿病的肾脏风险明显低于I型糖尿病，因为前者只有约5%会出现肾衰竭，而后者有40%会出现肾衰竭。基于我们在海德堡大学糖尿病门诊的观察，我们得出结论，非蛋白尿性II型糖尿病患者发生蛋白尿的累积风险以及蛋白尿性II型糖尿病患者发生肾衰竭的累积风险，与I型糖尿病患者的相应风险相当。这一观察结果值得注意，因为在早期II型糖尿病中，尚无关于超滤的无争议证据。II型糖尿病可能是检验超滤理论的一个有趣模型。
