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新型镁-纳米氟化磷灰石金属基纳米复合材料,具有改善的生物降解性能。

Novel magnesium-nanofluorapatite metal matrix nanocomposite with improved biodegradation behavior.

机构信息

Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.

出版信息

J Biomed Nanotechnol. 2011 Jun;7(3):441-5. doi: 10.1166/jbn.2011.1310.

Abstract

Designing and preparation of magnesium alloys with adjustable biocorrosion rates in the human body and precipitation ability of bone-like apatite layer have been of interest recently. Application of metal matrix composites (MMC) based on magnesium alloys might be an approach to this challenge. The aim of this work was fabrication and evaluation of biocorrosion and bioactivity of a novel MMC made of magnesium alloy AZ91 as matrix and fluorapatite (FA) nano particles as reinforcement. Biodegradable Magnesium-nano fluorapatite metal matrix nanocomposite (AZ91-20FA) was made via a blending-pressing-sintering method. In vitro corrosion tests were performed for evaluation of biocorrosion behavior of produced AZ91-20FA nanocomposite. The results showed that the addition of FA nano particles to magnesium alloy can reduce not only the corrosion rate in a simulated body environment but also accelerate the formation of an apatite layer.

摘要

最近,设计和制备可调节人体生物腐蚀性和具有骨样磷灰石层析出能力的镁合金引起了人们的兴趣。基于镁合金的金属基复合材料(MMC)的应用可能是解决这一挑战的一种方法。本工作的目的是制备和评估新型镁合金 AZ91 为基体和氟磷灰石(FA)纳米粒子为增强相的 MMC 的生物腐蚀性和生物活性。采用混料-压制-烧结法制备可降解镁-纳米氟磷灰石金属基纳米复合材料(AZ91-20FA)。通过体外腐蚀试验评价了所制备的 AZ91-20FA 纳米复合材料的生物腐蚀性行为。结果表明,在镁合金中添加 FA 纳米粒子不仅可以降低在模拟体液中的腐蚀速率,还可以加速磷灰石层的形成。

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