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通过电泳沉积羟基磷灰石涂层控制用于骨科应用的可生物降解Mg-Zn-Mn合金的降解速率

Controlling the Degradation Rate of Biodegradable Mg-Zn-Mn Alloys for Orthopedic Applications by Electrophoretic Deposition of Hydroxyapatite Coating.

作者信息

Antoniac Iulian, Miculescu Florin, Cotrut Cosmin, Ficai Anton, Rau Julietta V, Grosu Elena, Antoniac Aurora, Tecu Camelia, Cristescu Ioan

机构信息

Faculty of Materials Science and Engineering, Politehnica University of Bucharest, 313 Splaiul Independentei, District 6, 060042 Bucharest, Romania.

Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 7 Gheorghe Polizu, District 1, 011061 Bucharest, Romania.

出版信息

Materials (Basel). 2020 Jan 7;13(2):263. doi: 10.3390/ma13020263.

DOI:10.3390/ma13020263
PMID:31936095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7013831/
Abstract

Magnesium alloys as bioresorbable materials with good biocompatibility have raised a growing interest in the past years in temporary implant manufacturing, as they offer a steady resorption rate and optimal healing in the body. Magnesium exhibits tensile strength properties similar to those of natural bone, which determines its application in load-bearing mechanical medical devices. In this paper, we investigated the biodegradation rate of Mg-Zn-Mn biodegradable alloys (ZMX410 and ZM21) before and after coating them with hydroxyapatite (HAP) via the electrophoretic deposition method. The experimental samples were subjected to corrosion tests to observe the effect of HAP deposition on corrosion resistance and, implicitly, the rate of biodegradation of these in simulated environments. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) provided detailed information on the quality, structure, and morphology of the HAP coating. The obtained results demonstrate that coating of Mg-Zn-Mn alloys by HAP led to the improvement of corrosion resistance in simulated environments, and that the HAP coating could be used in order to control the biodegradation rate.

摘要

镁合金作为具有良好生物相容性的可生物吸收材料，在过去几年中，由于其具有稳定的吸收率和在体内的最佳愈合效果，在临时植入物制造方面引起了越来越多的关注。镁的拉伸强度特性与天然骨相似，这决定了它在承重机械医疗设备中的应用。在本文中，我们研究了通过电泳沉积法在Mg-Zn-Mn可生物降解合金（ZMX410和ZM21）上涂覆羟基磷灰石（HAP）前后的生物降解速率。对实验样品进行腐蚀测试，以观察HAP沉积对耐腐蚀性的影响，并含蓄地观察它们在模拟环境中的生物降解速率。X射线衍射（XRD）、扫描电子显微镜（SEM）和能量色散光谱（EDS）提供了有关HAP涂层质量、结构和形态的详细信息。所得结果表明，用HAP涂覆Mg-Zn-Mn合金可提高其在模拟环境中的耐腐蚀性，并且HAP涂层可用于控制生物降解速率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/e434bfeda75d/materials-13-00263-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/1a02a6ec0693/materials-13-00263-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/03e7108f689c/materials-13-00263-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/e434bfeda75d/materials-13-00263-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/a09a2a345284/materials-13-00263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/671d4cded19d/materials-13-00263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/59b25b8d72fa/materials-13-00263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/79a60e1360a9/materials-13-00263-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/1a02a6ec0693/materials-13-00263-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/e997b4c6498d/materials-13-00263-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/03e7108f689c/materials-13-00263-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b1/7013831/e434bfeda75d/materials-13-00263-g008.jpg

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