Hilton C W, Prasad C, Wilber J F
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Neuropeptides. 1990 Jan;15(1):55-9. doi: 10.1016/0143-4179(90)90161-q.
We analyzed the response of plasma cyclo(His-Pro) (CHP) (N = 14), insulin (N = 8), and glucose (N = 8) to oral ingestion of 75 grams of glucose in normal volunteers. Mean Fasting CHP levels prior to glucose were 614 +/- 112 pg/ml (+/-SE). After glucose ingestion there occurred an acute rise of plasma CHP within 15 minutes (12/14) followed by a fall in plasma concentrations to below baseline values (11 of 14). The mean of highest levels within the first 15 minutes after glucose ingestion was 1035 +/- 300 pg/ml (+/-SE), significantly above baseline (p = 0.002). The mean of lowest values below baseline was 490 +/- 94 pg/ml (+/-SE), p less than 0.001. We conclude that levels of CHP are acutely and reversibly altered by the ingestion of glucose. The possible significance of these perturbations in CHP concentrations is discussed.
我们分析了正常志愿者口服75克葡萄糖后血浆环（组氨酸-脯氨酸）（CHP）（N = 14）、胰岛素（N = 8）和葡萄糖（N = 8）的反应。葡萄糖摄入前的平均空腹CHP水平为614±112皮克/毫升（±标准误）。摄入葡萄糖后，15分钟内血浆CHP出现急性升高（14例中有12例），随后血浆浓度降至基线值以下（14例中有11例）。葡萄糖摄入后前15分钟内最高水平的平均值为1035±300皮克/毫升（±标准误），显著高于基线水平（p = 0.002）。低于基线的最低值平均值为490±94皮克/毫升（±标准误），p < 0.001。我们得出结论，摄入葡萄糖会使CHP水平发生急性且可逆的改变。本文讨论了CHP浓度这些波动的可能意义。
