Breit Samuel N, Johnen Heiko, Cook Andrew D, Tsai Vicky W W, Mohammad Mohammad G, Kuffner Tamara, Zhang Hong Ping, Marquis Christopher P, Jiang Lele, Lockwood Glen, Lee-Ng Michelle, Husaini Yasmin, Wu Liyun, Hamilton John A, Brown David A
St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
Growth Factors. 2011 Oct;29(5):187-95. doi: 10.3109/08977194.2011.607137. Epub 2011 Aug 11.
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause mortality, suggesting a fundamental role in biological processes associated with ageing. In cancer, the data available suggest that MIC-1/GDF15 is antitumorigenic, but this may not always be the case as disease progresses. Cancer promoting effects of MIC-1/GDF15 may be due, in part, to effects on antitumour immunity. This is suggested by the anti-inflammatory and immunosuppressive properties of MIC-1/GDF15 in animal models of atherosclerosis and rheumatoid arthritis. Furthermore, in late-stage cancer, large amounts of MIC-1/GDF15 in the circulation suppress appetite and mediate cancer anorexia/cachexia, which can be reversed by monoclonal antibodies in animals. Available data suggest MIC-1/GDF15 may be an important molecule mediating the interplay between cancer, obesity and chronic inflammation.
巨噬细胞抑制细胞因子-1（MIC-1/GDF15）与心血管疾病、炎症、体重调节及癌症相关。其血清水平有助于癌症和血管疾病的诊断及预后评估。此外，其血清水平是全因死亡率的有力预测指标，提示其在与衰老相关的生物学过程中发挥着重要作用。在癌症方面，现有数据表明MIC-1/GDF15具有抗肿瘤作用，但随着疾病进展情况可能并非总是如此。MIC-1/GDF15的促癌作用可能部分归因于其对抗肿瘤免疫的影响。这在动脉粥样硬化和类风湿关节炎动物模型中MIC-1/GDF15的抗炎和免疫抑制特性中得到了体现。此外，在癌症晚期，循环中大量的MIC-1/GDF15会抑制食欲并介导癌症恶病质/恶液质，在动物模型中可通过单克隆抗体逆转。现有数据表明MIC-1/GDF15可能是介导癌症、肥胖和慢性炎症之间相互作用的重要分子。
