St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, New South Wales, 2010, Australia.
St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, New South Wales, 2010, Australia.
Trends Mol Med. 2017 Dec;23(12):1065-1067. doi: 10.1016/j.molmed.2017.10.005. Epub 2017 Nov 9.
Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFβ) superfamily cytokine implicated in biological and disease processes including metabolism, cancer, and chronic inflammation, but whose receptor has remained elusive. Four laboratories have recently identified GFRAL, an orphan receptor of the glial-derived neurotrophic factor (GDNF) receptor α family, as the receptor for MIC-1/GDF15, signaling though the coreceptor Ret. These data identify a new systemic to central nervous system (CNS) circuit that regulates metabolism in response to stress and which could be targeted to treat both severe obesity and anorexia/cachexia syndrome.
巨噬细胞抑制细胞因子-1/生长分化因子 15（MIC-1/GDF15）是一种分化的转化生长因子（TGFβ）超家族细胞因子，涉及包括代谢、癌症和慢性炎症在内的生物学和疾病过程，但它的受体一直难以捉摸。最近，四个实验室已经鉴定出 GFRAL，一种神经胶质衍生神经营养因子（GDNF）受体α家族的孤儿受体，是 MIC-1/GDF15 的受体，通过辅助受体 Ret 信号传导。这些数据确定了一个新的系统到中枢神经系统（CNS）的回路，该回路调节应激反应中的代谢，这可能成为治疗严重肥胖和厌食/恶病质综合征的靶点。
