Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain.
Int J Dent Hyg. 2012 May;10(2):98-106. doi: 10.1111/j.1601-5037.2011.00523.x. Epub 2011 Aug 10.
the aim of this study was to evaluate the effects of the use of a mouth rinse and dentifrice with cetylpyridinium chloride (CPC) in patients with gingivitis.
the study was designed as a 1-month, double-blind, parallel, randomized clinical trial comparing a negative control regimen (minus active ingredients dentifrice and mouth rinse) with the test products (dentifrice and mouth rinse with 0.05% CPC) in terms of plaque and gingival indexes (PI, GI), patient-based and microbiological outcome variables. The comparisons in relation to the main outcome variables (PI and GI) were made by means of the t-test, either unpaired or paired for the intergroup and intragroup comparisons, respectively.
no differences were detected at baseline. Both groups showed statistically significant decreases in GI (0.17-0.19), without intergroup differences. The PI demonstrated a significant decrease of -0.12 in the test group and minor changes in the negative control group (increase of +0.01). Differences between groups showed a tendency towards statistical significance. A limited impact was observed for microbiological variables in both groups.
the results of this study show limited benefits of the evaluated formulations as adjuncts to unsupervised oral hygiene in reducing plaque accumulation, and no effect on gingivitis.
本研究旨在评估使用含有氯化十六烷基吡啶（CPC）的漱口液和牙膏对牙龈炎患者的影响。
该研究设计为为期 1 个月的双盲、平行、随机临床试验，比较阴性对照组（不含活性成分牙膏和漱口液）与试验产品（含 0.05% CPC 的牙膏和漱口液）在菌斑和牙龈指数（PI、GI）、患者为基础和微生物学结果变量方面的差异。主要观察指标（PI 和 GI）的比较采用 t 检验，分别为组间和组内比较的非配对或配对检验。
基线时无差异。两组的 GI（0.17-0.19）均有统计学显著下降，组间无差异。PI 在试验组有显著下降（-0.12），而阴性对照组仅有轻微变化（增加 0.01）。组间差异有统计学意义的趋势。两组的微生物学变量均观察到有限的影响。
本研究结果显示，评估的配方作为非监督口腔卫生的辅助手段，在减少菌斑积聚方面的益处有限，对牙龈炎没有影响。
