Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Trends Biotechnol. 2012 Jan;30(1):55-63. doi: 10.1016/j.tibtech.2011.07.002. Epub 2011 Aug 9.
Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are promising because they can repopulate lost or damaged cells and tissues. However, the adult CNS does not provide an optimal milieu for exogenous NSPCs to survive, engraft, differentiate, and integrate with host tissues. This review provides an overview of tissue engineering strategies to improve stem cell therapies by providing a defined microenvironment during transplantation. The use of biomaterials for physical support, growth factor delivery, and cellular co-transplantation are discussed. Providing the proper environment for stem cell survival and host tissue integration is crucial in realizing the full potential of these cells in CNS repair strategies.
中枢神经系统（CNS）的创伤性损伤极具危害性，再生治疗的临床需求显而易见。神经干细胞/祖细胞（NSPCs）具有广阔的应用前景，因为它们可以补充丢失或受损的细胞和组织。然而，成年 CNS 并不能为外源 NSPC 提供一个理想的微环境，使其存活、植入、分化并与宿主组织整合。本综述概述了组织工程策略，通过在移植过程中提供一个明确的微环境来改善干细胞治疗。讨论了生物材料在物理支持、生长因子传递和细胞共移植中的应用。为干细胞的存活和宿主组织的整合提供适当的环境对于实现这些细胞在 CNS 修复策略中的全部潜力至关重要。
