非编码 RNA 和增强子：长距离关系的复杂性。
Noncoding RNAs and enhancers: complications of a long-distance relationship.
机构信息
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
出版信息
Trends Genet. 2011 Oct;27(10):433-9. doi: 10.1016/j.tig.2011.06.009. Epub 2011 Aug 9.
Abstract
Spatial and temporal regulation of gene expression is achieved through instructions provided by the distal transcriptional regulatory elements known as enhancers. How enhancers transmit such information to their targets has been the subject of intense investigation. Recent advances in high throughput analysis of the mammalian transcriptome have revealed a surprising result indicating that a large number of enhancers are transcribed to noncoding RNAs. Although long noncoding RNAs were initially shown to confer epigenetic transcriptional repression, recent studies have uncovered a role for a class of such transcripts in gene-specific activation, often from distal genomic regions. In this review, we discuss recent findings on the role of long noncoding RNAs in transcriptional regulation, with an emphasis on new developments on the functional links between long noncoding RNAs and enhancers.
摘要
通过来自远端转录调控元件（如增强子）的指令实现基因表达的时空调控。增强子如何将这些信息传递到靶基因一直是研究的热点。近年来，对哺乳动物转录组的高通量分析取得了一些进展，结果令人惊讶，大量的增强子被转录为非编码 RNA。尽管长非编码 RNA 最初被证明可以赋予表观遗传转录抑制，但最近的研究揭示了一类此类转录物在基因特异性激活中的作用，通常来自远端基因组区域。在这篇综述中，我们讨论了长非编码 RNA 在转录调控中的作用的最新发现，重点介绍了长非编码 RNA 与增强子之间功能联系的新进展。
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