School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, United Kingdom.
Trends Cogn Sci. 2011 Sep;15(9):395-400. doi: 10.1016/j.tics.2011.07.007. Epub 2011 Aug 9.
The first candidate gene studies of human personality promised much but, in the fifteen years since their publication, have delivered little in the way of clear evidence for the contribution of specific genetic variants to observed variation in personality traits. This is most likely due to the very small effects conferred by individual loci. The advent of genome-wide association studies has brought growing awareness that high levels of statistical stringency, very large sample sizes, and independent replication will be minimum requirements for future genetic studies of personality. At the same time, evidence from other fields indicates that the genetic architecture of personality is likely to consist of the combined effect of many hundreds, if not thousands, of small effect loci.
对人类个性的第一个候选基因研究承诺很多，但在它们发表后的十五年里，几乎没有明确的证据表明特定的遗传变异对个性特征的观察到的变化有贡献。这很可能是由于单个基因座赋予的影响非常小。全基因组关联研究的出现使人们越来越意识到，对于未来的人格遗传研究，高水平的统计严格性、非常大的样本量和独立复制将是最低要求。与此同时，来自其他领域的证据表明，个性的遗传结构很可能由数百个（如果不是数千个）小效应基因座的共同作用组成。
