lysS和lysU的同源性，这两个大肠杆菌基因编码不同种类的赖氨酰-tRNA合成酶。
Homology of lysS and lysU, the two Escherichia coli genes encoding distinct lysyl-tRNA synthetase species.
作者信息
Lévêque F, Plateau P, Dessen P, Blanquet S
机构信息
Laboratoire de Biochimie de l'Ecole Polytechnique, Unité associée 240 du Centre National de la Recherche Scientifique, Palaiseau, France.
出版信息
Nucleic Acids Res. 1990 Jan 25;18(2):305-12. doi: 10.1093/nar/18.2.305.
Abstract
In Escherichia coli, two distinct lysyl-tRNA synthetase species are encoded by two genes: the constitutive lysS gene and the thermoinducible lysU gene. These two genes have been isolated and sequenced. Their nucleotide and deduced amino acid sequences show 79% and 88% identity, respectively. Codon usage analysis indicates the lysS product being more efficiently translated than the lysU one. In addition, the lysS sequence exactly coincides with the sequence of herC, a gene which is part of the prfB-herC operon. In contrast to the recent proposal of Gampel and Tzagoloff (1989, Proc. Natl. Acad. Sci. USA 86, 6023-6027), the lysU sequence is distinct from the open reading frame located adjacent to frdA, although large homologies are shared by these two genes.
摘要
在大肠杆菌中，两个不同的赖氨酰 - tRNA合成酶由两个基因编码：组成型的lysS基因和热诱导型的lysU基因。这两个基因已被分离并测序。它们的核苷酸序列和推导的氨基酸序列分别显示出79%和88%的同一性。密码子使用分析表明，lysS产物的翻译效率比lysU产物更高。此外，lysS序列与herC的序列完全一致，herC是prfB - herC操纵子的一部分。与甘佩尔和察戈洛夫最近的提议（1989年，《美国国家科学院院刊》86，6023 - 6027）相反，尽管这两个基因有很大的同源性，但lysU序列与位于frdA相邻位置的开放阅读框不同。
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