de Araujo Melissa Rodrigues, Scariot Rafaela, Uetanabaro Lucas, Luvison Gomes da Silva Larissa, Giovanini Allan Fernando
Professor of the Graduate Program in Clinical Dentistry, Positivo University, Paraná, Brazil.
Professor of the Graduate Program in Clinical Dentistry, Positivo University, Paraná, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Oct;120(4):e177-82. doi: 10.1016/j.oooo.2015.01.015. Epub 2015 Feb 7.
Xanthoma is a very rare bone tumor, especially in the mandible, that can be associated with metabolic diseases such as hyperlipidemia. A 14-year-old girl presented with a non-corticated unilocular radiolucent lesion observed on panoramic radiography. The lesion was located between the roots of the left first and second premolar teeth, extending from the cervical to the apical region, measuring approximately 1 cm in greatest dimension. An excisional biopsy revealed foam cells and occasional nonfoamy mononuclear macrophage-like cells spread among a discrete fibrous stroma. Immunohistochemically, the xanthomatous cells were CD68 and vimentin positive, focally positive for S100, CD1a, and CD3 and negative for AE1/AE3, CD20, CD117, and HMB45. Hematologic and biochemical investigations ruled out systemic disease.
黄色瘤是一种非常罕见的骨肿瘤，尤其好发于下颌骨，可与高脂血症等代谢性疾病相关。一名14岁女孩在全景X线片上表现为一个非皮质性单房性透射性病变。该病变位于左侧第一和第二前磨牙牙根之间，从颈部延伸至根尖区，最大直径约为1 cm。切除活检显示泡沫细胞和偶尔的非泡沫单核巨噬细胞样细胞散布于离散的纤维基质中。免疫组化显示，黄色瘤细胞CD68和波形蛋白阳性，S100、CD1a和CD3局灶性阳性，AE1/AE3、CD20、CD117和HMB45阴性。血液学和生化检查排除了全身性疾病。
