Oxford Kidney Unit, The Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK.
Nephron Clin Pract. 2011;119 Suppl 1:c2-4. doi: 10.1159/000328013. Epub 2011 Aug 10.
The average glomerular filtration rate (GFR) is lower in the elderly than in the young and is usually a consequence of biological ageing, the rate of which varies between individuals. In some subjects, the decline is aggravated by concomitant vascular disease. The prevalence of significant kidney disease in the elderly has been overestimated - largely by rendering a diagnosis of chronic kidney disease by reference to estimates of GFR which are found in the young. A stable low GFR in the elderly, provided it is physiologically sufficient to meet homeostatic demands, is not a disease per se and seldom progresses to true kidney failure. However, it can be a risk factor for acute kidney injury drug misdosing, and possibly cardiovascular disease, so it should be noted.
老年人的平均肾小球滤过率（GFR）低于年轻人，通常是生物衰老的结果，衰老的速度因人而异。在某些情况下，血管疾病的并发会加重 GFR 的下降。老年人中严重肾脏疾病的患病率被高估了——主要是因为通过参考年轻人的 GFR 估计值来诊断慢性肾脏病。老年人稳定的低 GFR，如果生理上足以满足体内平衡的需求，本身并不是一种疾病，很少会进展为真正的肾衰竭。然而，它可能是急性肾损伤药物剂量错误和可能的心血管疾病的危险因素，因此应该注意。
