Front D, Israel O, Epelbaum R, Ben Haim S, Sapir E E, Jerushalmi J, Kolodny G M, Robinson E
Department of Nuclear Medicine, Rambam Medical Center, Haifa, Israel.
Radiology. 1990 May;175(2):515-9. doi: 10.1148/radiology.175.2.2183289.
The results of planar and single photon emission computed tomography (SPECT) gallium-67 scintigraphy performed before and after treatment were compared in 77 patients with lymphoma at 240 sites. Before treatment, the sensitivity of planar scintigraphy was 78% and the specificity was 97%; after treatment, 84% and 96%, respectively. Before treatment, SPECT had a sensitivity of 85% and a specificity of 98%; after treatment, 92% and 99%, respectively. In addition, SPECT allowed better anatomical localization and showed the entire extent of lesions at 36 sites. SPECT was of special value after treatment in excluding disease at 16 sites with residual masses seen at computed tomography (CT). Long-term follow-up in these patients showed that their condition was in complete remission and that the CT appearance of a residual mass does not always mean residual cancer. Thus, Ga-67 SPECT is a suitable imaging technique for monitoring the response of lymphoma to treatment.
对77例淋巴瘤患者240个部位治疗前后进行的平面和单光子发射计算机断层扫描（SPECT）镓-67闪烁显像结果进行了比较。治疗前，平面闪烁显像的敏感性为78%，特异性为97%；治疗后分别为84%和96%。治疗前，SPECT的敏感性为85%，特异性为98%；治疗后分别为92%和99%。此外，SPECT能更好地进行解剖定位，并显示了36个部位病变的全貌。SPECT在治疗后对于排除计算机断层扫描（CT）显示有残留肿块的16个部位的疾病具有特殊价值。对这些患者的长期随访表明他们的病情完全缓解，CT上残留肿块的表现并不总是意味着残留癌症。因此，镓-67 SPECT是监测淋巴瘤治疗反应的合适成像技术。
