Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia.
Molecules. 2011 Aug 10;16(8):6833-43. doi: 10.3390/molecules16086833.
New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one, 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one, 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide, 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one were prepared starting from the natural compound umbelliferone. The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, ¹H-NMR and ¹³C-NMR).
新型香豆素衍生物，即 7-[(5-氨基-1,3,4-噻二唑-2-基)甲氧基]-2H-色烯-2-酮、5-[(2-氧代-2H-色烯-7-基氧基)甲基]-1,3,4-噻二唑-2(3H)-酮、2-[2-(2-氧代-2H-色烯-7-基氧基)乙酰基]-N-苯基腙硫代甲酰胺、7-[(5-(苯基氨基)-1,3,4-噻二唑-2-基)甲氧基]-2H-色烯-2-酮和 7-[(5-巯基-4-苯基-4H-1,2,4-三唑-3-基)甲氧基]-2H-色烯-2-酮，均由天然化合物茴芹香豆素合成。新合成的化合物通过元素分析和光谱研究（IR、¹H-NMR 和 ¹³C-NMR）进行了表征。
