利用伞形酮合成新杂环化合物。
The use of umbelliferone in the synthesis of new heterocyclic compounds.
机构信息
Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia.
出版信息
Molecules. 2011 Aug 10;16(8):6833-43. doi: 10.3390/molecules16086833.
New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one, 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one, 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide, 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one were prepared starting from the natural compound umbelliferone. The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, ¹H-NMR and ¹³C-NMR).
新型香豆素衍生物，即 7-[(5-氨基-1,3,4-噻二唑-2-基)甲氧基]-2H-色烯-2-酮、5-[(2-氧代-2H-色烯-7-基氧基)甲基]-1,3,4-噻二唑-2(3H)-酮、2-[2-(2-氧代-2H-色烯-7-基氧基)乙酰基]-N-苯基腙硫代甲酰胺、7-[(5-(苯基氨基)-1,3,4-噻二唑-2-基)甲氧基]-2H-色烯-2-酮和 7-[(5-巯基-4-苯基-4H-1,2,4-三唑-3-基)甲氧基]-2H-色烯-2-酮，均由天然化合物茴芹香豆素合成。新合成的化合物通过元素分析和光谱研究（IR、¹H-NMR 和 ¹³C-NMR）进行了表征。
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