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高效催化剂一锅法合成7-(芳基)-10,10-二甲基-10,11-二氢苯并色烯并[4,3-b]苯并色烯-6,8(7H,9H)-二酮衍生物及其抗菌活性补充

Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity.

作者信息

Al-Majedy Yasameen K, Al-Amiery Ahmed A, Kadhum Abdul Amir H, Mohamad Abu Bakar

机构信息

Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, Malaysia.

Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), 43000 Bangi, Selangor, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad 10001, Iraq.

出版信息

Biomed Res Int. 2016;2016:5891703. doi: 10.1155/2016/5891703. Epub 2016 Jul 31.

DOI:10.1155/2016/5891703
PMID:27563671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4983404/
Abstract

The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity.

摘要

细菌对许多已知药物产生耐药性的问题促使科学家和研究人员去发现新型高效的抗菌药物。开发了三种快速、清洁且高效的方法用于一锅法合成7-(芳基)-10,10-二甲基-10,11-二氢苯并色烯并[4,3-b]色烯-6,8(7H,9H)-二酮衍生物。在合成过程中，使用四丁基溴化铵(TBAB)、磷酸氢二铵(DAHP)或氯化铁(FeCl₃)分别使三种组分4-羟基香豆素、5,5-二甲基-1,3-环己二酮和芳香醛缩合。根据催化剂的不同，每种方法都有不同的反应机理。目前的方法具有一锅法合成、产率高、反应时间短以及产物易于分离等优点。我们研究中使用的所有催化剂都可以重复使用几次而不丧失其催化效率。所有合成的化合物都进行了全面表征并评估了它们的抗菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/0efea9a440f8/BMRI2016-5891703.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/3e0583a8c4ad/BMRI2016-5891703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/32dcd9a7ecf7/BMRI2016-5891703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/13eec5c202f3/BMRI2016-5891703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/cd6bd4b894cb/BMRI2016-5891703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/5572a7f2d97c/BMRI2016-5891703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/6d8f0de9d1c3/BMRI2016-5891703.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/ce3116644cbb/BMRI2016-5891703.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/0efea9a440f8/BMRI2016-5891703.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/3e0583a8c4ad/BMRI2016-5891703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/32dcd9a7ecf7/BMRI2016-5891703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/13eec5c202f3/BMRI2016-5891703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/cd6bd4b894cb/BMRI2016-5891703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/5572a7f2d97c/BMRI2016-5891703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/6d8f0de9d1c3/BMRI2016-5891703.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/ce3116644cbb/BMRI2016-5891703.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecc/4983404/0efea9a440f8/BMRI2016-5891703.008.jpg

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