Cardiovascular Research Center, Mount Sinai School of Medicine, New York, New York, USA.
Clin Pharmacol Ther. 2011 Oct;90(4):620-4. doi: 10.1038/clpt.2011.161. Epub 2011 Aug 10.
Heart failure (HF) has reached epidemic proportions in the United States and is one of the most important challenges to public health. Severe congestive HF is associated with substantial morbidity and mortality. HF afflicts approximately 5 million patients and contributes to 3 million hospitalizations and 300,000 deaths yearly. Late-stage HF has a poor prognosis, and therapeutic options are limited. Defective excitation–contraction (EC) coupling in HF may result from altered density or function of proteins relevant for Ca2+ homeostasis.
心力衰竭（HF）在美国已达到流行程度，是对公共卫生的最重要挑战之一。严重充血性 HF 与大量发病率和死亡率相关。HF 影响大约 500 万名患者，每年导致 300 万住院和 30 万人死亡。晚期 HF 预后不良，治疗选择有限。HF 中的兴奋-收缩（EC）偶联的缺陷可能是由于与 Ca2+稳态相关的蛋白质的密度或功能改变所致。
