Dilovski M
Vet Med Nauki. 1978;15(6):15-20.
The Swine Vesicular Disease virus yields a heterogenic plaque population consisting of large round plaques of 8-10 mm, small uniform plaques with slightly indented contours, measuring 1-3 mm, and single plaques of transient form and size. The reisolates of the large (Lpf) plaques give a population that is similar to the initial virus, while the cloning of the small (Mpf) plaques leads to a homogenic population of such plaques. In vivo, the virus of the large plaques manifests enhanced virulence for swine. On the other hand, the selected small-plaque variant is apathogenic, which makes it possible to produce a live avirulent vaccine.
猪水疱病病毒产生一种异质性蚀斑群体，由直径8 - 10毫米的大圆形蚀斑、轮廓略有凹陷、直径1 - 3毫米的小均匀蚀斑以及形态和大小各异的单个蚀斑组成。大蚀斑（Lpf）的再分离物产生的群体与初始病毒相似，而小蚀斑（Mpf）的克隆则导致此类蚀斑的同质性群体。在体内，大蚀斑病毒对猪表现出增强的毒力。另一方面，所选的小蚀斑变体无致病性，这使得生产减毒活疫苗成为可能。
