Niemiałtowski M
Acta Virol. 1983 May;27(3):223-7.
From wild swine vesicular disease virus (SVDV) strains temperature-dependent (td) mutants td 27 degrees C, td 32 degrees C and td 42 degrees C were derived. Differences were noted in their pathogenicity for newborn mice. The non-homogeneity of the td populations was manifested by formation of plaques of various sizes and confirmed by differential pathogenicity of the clones derived from them. A higher pathogenicity of the td mutants and their clones was associated not only with larger plaques, but also with higher temperature permissive for the given mutant. The td 27 degrees C mutants were not virulent for newborn mice, similarly to the attenuated SVDV strain and its clones.
从野生猪水泡病病毒（SVDV）毒株中衍生出温度依赖性（td）突变体td 27℃、td 32℃和td 42℃。观察到它们对新生小鼠的致病性存在差异。td群体的非均一性表现为形成大小各异的噬菌斑，并通过从它们衍生出的克隆的不同致病性得到证实。td突变体及其克隆的较高致病性不仅与较大的噬菌斑有关，还与给定突变体允许的较高温度有关。td 27℃突变体对新生小鼠无致病性，类似于减毒SVDV毒株及其克隆。
